3Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory eytokine production in rat acute liver injury. Free radical Research, 2002 , 37 ( 8 ) : 849-859.
4Mikawa K, Akamatsu H, Nishina K, et al. Effects of edaravone on human neutrophil function. Acta Anaesthesiol Scand,2005, 49(3) : 385-389
6Mizuno A, Umemura K, Nakashima M, et al. Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle artery occlusion. Gen pharmaco, 1998, 30(4): 575-578.
7Watanabe T, Egawa M. Effects of an antistroke agent MCI-186 on cerebral arachidonatc cascades. J Pharmacol Exp Ther,1994, 271(3): 1624-1629.
8Shichinohe H, Kuroda S, Yasuda H, et al. neuroprotective effects of the free radical (MCI-186) in mice permanent focal brain ischemia. Brain Res, 2004, 1029(2): 200-206.
9Amemiya S, Kamiya K Nito C, et al. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J, 2005, 6(1) : 125-130.
10Yasuoka N, Nakajima W, Ishida A, et al. Neuroprotection of edaravone of hypoxic-ischemic brain injury in neonatal rats.Brain Res Dev Brain Res, 2004, 7(19) : 129-139.
5Fukuuchi Y.Recent advances in pathophysiology and treat- ment of acute ischemic stroke[J].Rinsho Shinkeigaku, 1998, 38(12): 1001-1004.
6Castillo J,Leira R,Garcfa MM,et al.Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome [J].Stroke,2004,35 (2) :520-526.
7Imamura M,Kiguchi S, Kobayashi K,et al.Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor,on cere- bral infarction in rats.Comparative study with norphenazone, a free-radical scavenger[J].Arzneimittelforschung, 2003,53 (10) : 688-694.
