替吉奥联合顺铂治疗晚期胃癌近期疗效观察

Recent Efficacy of S-1 Combined with Cisplatin in the Treatment of Patients with Advanced Gastric Carcinoma

目的观察替吉奥胶囊（S-1）联合顺铂治疗晚期胃癌的近期疗效和毒副反应。方法初治和复治的晚期胃癌53例，替吉奥胶囊每天80mg／m2，2次／d，口服14d，停药7d；顺铂75mg／ml，d1～3静脉滴注，21d为1个周期，2周期后评价疗效。结果总有效率为67．9％（36／53），主要毒副反应为胃肠道反应，Ⅲ～Ⅳ度的白细胞减少占13．2％（7／53）。结论替吉奥胶囊联合顺铂方案治疗晚期胃癌是有效、安全的。

Objective To evaluate the efficacy and toxicity of the combination of S-1 and cisplation in the treatment of patients with advanced gastric carcinoma. Methods 53 patients with advanced gastric carcinoma were treated with S-1 plus c isplatin, 80 mg·m2. d·S-1 was given orally for 14 days, twice one day, drug withdrawal for 7 days; 75 mg/m~ cisplatin was intravenously injected for 1 - 3 days, 21 d was a cycle, the efficacy was evaluated after 2 cycles. Results The total effective rate was 67.9% （36/53）, the main side effects were gas- trointestinal reactions, the decrease of grade Ⅲ-Ⅳ leukcocytes accounted for 13.2% （7/53）. Conclusion S-1 combined with cisplatin for the treatment of advanced gastric carcinoma is effective and safe.