六味地黄汤加味治疗强直性脊柱炎的临床研究

Clinical Study of Liuwei Dihuang Tang for the Treatment of Ankylosing Spondylitis

目的观察六味地黄汤加味治疗肝肾不足、湿热痹阻型强直性脊柱炎(AS)的疗效和安全性。方法本研究采用临床随机对照试验方法。将64例符合标准的患者随机分成两组。治疗组:32例,口服六味地黄汤加味;对照组:32例,口服甲氨喋呤+柳氮磺吡啶,两组疗程均为3个月。结果经治疗,两组晨僵持续时间、Schober实验、胸廓扩张度、血沉(ESR)及C反应蛋白(CRP)等指标较治疗前均显著降低(P<0.05),并且治疗组改善程度明显大于对照组(P<0.05);治疗组不良反应发生率明显少于对照组(P<0.05)。结论六味地黄汤加味是治疗肝肾不足、湿热痹阻型强直性脊柱炎安全而有效的方法。

Objective To observe the efficacy and safety of liuwei dihuang tang for the treatment of ankylosing spondylitis with syn- drome of deficiency of the liver and kidney and internal retention of damp-heat. Methods According to randomized controlled trial, 64 pa- tients with ankylosing spondylitis were randomly divided into two groups： the experimental group （32 cases） was orally administrated with liuwei dihuang tang; the control group （32 cases） with MTX ＋ SASP, the therapeutic course for both groups was 3 months. Results After treatment, there was significant improvement in indexes （including duration of morning stiffness, schober test, chest expansion, erythroeyte sedimentation rate （ESR）, C reaction protein （CRP）） in both groups as compared with baseline （P 〈0.05）, and the above indexes improved better in experiment group than those in the control group （P 〈0.05）; the side-effect rate was significantly lower in experiment group than that in control group （P〈0.05）. Conclusion Liuwei dihuang tang is a safe and effective method for ankylosing spondylitis.