动脉粥样硬化血栓形成型脑梗死急性期治疗与预后的关系

Relationships between treatment at acute stage and the prognosis in atherothrombosis ischemic stroke patients

目的探讨动脉粥样硬化血栓形成型脑梗死患者急性期抗血小板、调脂和抗氧化治疗与预后的关系。方法将689例动脉粥样硬化血栓形成型脑梗死患者根据是否服用抗血小板药物、他汀类调脂药物或抗氧化剂普罗布考分为观察组和对照组。随访12个月,根据改良Rankin量表评分评价两组的预后,比较两组的改善率、复发率、预后不良发生率和病死率。结果观察组的改善率高于对照组(P<0.05),观察组随访3、12个月的预后不良发生率和病死率明显低于对照组(P<0.05),两组复发率比较无统计学差异(P>0.05)。结论抗血小板、他汀类调脂治疗或抗氧化治疗能改善动脉粥样硬化血栓形成型脑梗死患者的预后,明显降低预后不良的发生率和病死率。

Objective To study the prognosis of atherothrombosis ischemic stroke patients with antiplatelet, lipid-low-ering or antioxidants therapy in the acute phase. Methods A total of 689 atherothrombosis ischemie stroke patients were divided into controlled groups and observed groups based on whether patients accepted antiplatelet, statins or probucol antioxidant therapy. The improvement rate, recurrence rate,the incidence of unfavorable prognosis and mortality rate were evaluated by modified Rankin scale （mRs） after 12 months follow-up. Results After three months and twelve months follow-up, the improvement rate was higher in observed groups, but the incidence of unfavorable prognosis and mortality rate were lower in observed groups than those in controlled groups （P 〈0.05 ） , however there were no statistically difference in recurrence rate between observed groups and controlled groups （P〉 0.05 ）. Conclusions Antiplatelet, statins lipid-low- ering or probueol antioxidant therapy in the acute phase can not only improve the prognosis of atherothrombosis ischemic stroke patients, but also decrease the incidence of unfavorable prognosis and mortality rate.