冠状动脉性心脏病患者血清抗心磷脂抗体检测的临床价值

THE CLINICAL OPPLICATION SERUM OF THE TESTING ANTIPHOSPHOLIPIDANTIBODY IN PATIENTS WITH CORONARY HEART DISEASE

目的观察CHD患者ACA水平,探讨ACA与CHD发生发展的关系。方法用ELISA法对250例CHD患者、120例健康者和47例其他心脏病患者进行ACA(IgGI、gMI、gA)检测,比较各组ACA平均结合指数。结果 CHD各组ACA平均结合指数明显高于正常对照组和非CHD心脏病组(P<0.01),急性心肌梗死组尤其显著。结论检测CHD患者血清中IgG-ACA和IgM-ACA的含量对CHD的诊断与病情分析有重要意义,尤其对急性心梗的病情转归更有临床应用价值。

Objective To observe the levels of Antiphospholipid antibody （ACA） in coronary heart disease （CHD） patients and to explore the relationship between the level of ACA and the development of CHD. Methods ELISA was used to determine the ACA（ IgG,IgM and IgA）levels in 212 coronary heart disease patients, 112 healthy subjects and 46 Non-coronary heart disease subjects. The median bound indexes were analyzed by t-test. Results The median bound indexes of CHD group were much higher, especially in the acute myocardial infarction （AMI） group,than in the healthy control group and in the non-corronary heart disease group. Conclusion The detections of the levels of IgG-ACA and IgM-ACA are valuable for the diagnosis and analysis of CHD, especially for the treatment of AMI.