间充质干细胞在类风湿关节炎中的研究进展

Research Progress on Application of Mesenchymal Stem Cells for Treating Rheumatoid Arthritis

类风湿关节炎(RA)发病机制较复杂,目前尚无有效药物根治。胶原诱导性关节炎与RA有相似的病理表现,是广泛用于研究RA的模型。尽管间充质干细胞(MSCs)通过抑制T细胞的增殖,调节有关细胞因子的分泌对胶原诱导性关节炎有效,但也有体内研究得出相反结论。关于MSCs应用于RA患者的研究很少,仅有个案报道有效。除以上争议外,MSCs应用于RA的安全性也应慎重考虑。

The pathogenesis of rheumatoid arthritis（RA）was complex,and so far,there were no effective drugs for radical cure.Because of the same symptoms collagen-induced arthritis was the model used widely for the study of RA.Although mesenchymal stem cells（MSCs）was proved to be effective to the collagen-induced arthritis through prohibiting the proliferation of the T cell and regulating the secretion relative cytokines,some studies have got the opposite conclusion in vivo.There were a few cases about the patients treated with MSCs,and only one case reported that treating with MSCs available.Besides those disputes,the security of applying MSCs should also be considered carefully.