PCI术后对比剂肾病的相关危险因素研究

The study of risk factors of contrast-induced nephropathy in patients after PCI

目的:研究冠心病患者经皮冠状动脉介入治疗(PCI)术后对比剂肾病(CIN)发生率及高危因素。方法:回顾性分析300例行PCI的冠心病患者肾功能情况、年龄、心功能、糖尿病、高血压、冠脉血管病变等与CIN的相关性,并记录CIN的发生情况。结果:CIN的发生率为14%,对CIN相关的临床因素进行Logistic回归分析发现,高龄、基础肌酐值>309.4μmol/L、内生肌酐清除率<45 mL/min、多支冠状动脉病变、心功能不全等与CIN发生密切相关(P<0.05)。而高血压和单纯糖尿病与CIN发生未见相关(P>0.05)。结论:高龄、肾功能不全、心功能不全、多支病变等可能是CIN发生的高危因素。高血压和单纯糖尿病未能证实是CIN发生的危险因素。

Objective： To study the incidence of CIN and the high risk factors of CIN after PCI in patients with coronary heart diseases.Methods：With a retrospective analysis of the patients who accepted PCI,300 patients were selected to analyze the relevance between renal function,age,heart function,diabetes,hypertension,coronary artery disease and CIN,and the incidence of CIN were record.Results： Clinical factors associated CIN Logistic regression analysis showed that old age,creatinine309.4μmol/L,endogenous creatinine clearance rate 45 mL/min,coronary multi-vessel disease,heart dysfunction were risk factors for CIN（P0.05）.And diabetes and hypertension were not risk factors for CIN（P0.05）.Conclusion：The elderly,renal insufficiency,heart failure,multi-vessel disease may be the high-risk factors for CIN.There are no definite evidences to verify that hypertension and diabetes are risk factors for CIN.