环丙沙星的极谱催化波研究

Study on the Polarographic Catalytic Behaviour of Ciprofloxacin

在０１ｍ ｏｌ／ＬＫＨ２ＰＯ４ＮａＯＨ（ｐＨ６．８±０２） 的缓冲溶液中，在Ｈ２Ｏ２存在下环丙沙星产生一极谱催化波，其二阶导数阴极催化波峰高与环丙沙星浓度在９８５×１０－ ７～１９７×１０－ ５ｍ ｏｌ／Ｌ范围内呈良好的线性关系，相关系数为０９９９７。该法已用于测定盐酸环丙沙星片中的环丙沙星的含量，结果满意。实验证明其电极过程具有吸附催化波的特征。

A polarographic adsorptive catalytic wave of ciprofloxacin(CF) was obtained by single sweep oscillopolarography in 0.1mol/L KH 2PO 4 NaOH (pH6.8) buffer solution containing 1.7×10 -2 mol/L H 2O 2.The peak potential appears at -1.16V.The peak height is linearly proportional to the concentration of CF over the range of 9.85×10 -7 ～1 97×10 -5 mol/L.The electrode process of the catalytic wave was discussed.