高血压患者高敏C-反应蛋白及脂联素与颈动脉粥样硬化的相关性研究

Correlation of C-reactive protein and adiponectin to carotidartery atherosclerosis in hypertensive patients

目的探讨高血压患者颈动脉粥样硬化与超敏C-反应蛋白、脂联素的相互关系及意义。方法根据双侧颈动脉超声指标,将226例高血压患者,分为无颈动脉斑块组(CA-1组,n=94)及颈动脉斑块形成组(CA-2组,n=132),以36例健康体检者为健康对照组。测定三组患者血清胰岛素、超敏C-反应蛋白、脂联素及双侧颈动脉超声等指标,半定量估计斑块的范围及严重程度。结果 (1)高血压病2个组的颈动脉内膜中层厚度、胰岛素抵抗指数、超敏C-反应蛋白等指标均显著高于对照组(P<0.01),脂联素则显著低于对照组(P<0.01);高血压病2个组间各指标相比较均有显著差异(P<0.01)。(2)颈动脉内膜中层厚度与胰岛素抵抗指数、超敏C-反应蛋白呈明显正相关(P<0.01),与脂联素呈明显负相关(P<0.01)。结论 C-反应蛋白、脂联素和胰岛素抵抗与高血压病患者颈动脉粥样硬化有关。

Objective To study the correlation of carotid atherosclerosis with C-reactive protein and adiponectin in hypertensive patients.Methods According to bilateral carotid artery echocardiography,226 hypertensive patients were divided into no carotid artery plaque group（CA-1 group,n=94）and carotid artery plaque group（CA-2 group,n=132）to 36 healthy normal control group.Serum insulin,high sensitivity C-reactive protein and adiponectin were tested and semi-quantitative estimates of the extent and severity of plaque of carotidartery were evaluated by ultrasonography.Results 1.Intima-media thickness（IMT）,insulin resistance index（HOMA-IR）,high sensitive C-reactive protein（hs-CRP）in CA-1 group and CA-2 group were significantly higher than those in control group（P〈0.01）,adiponectin was significantly lower than that in control group（P〈0.01）.There were significant difference in indexes above between CA-1 group and CA-2 group（P〈0.01）.2.IMT was positively correlated with HOMA-IR and hs-CRP（P〈0.01）,while negatively correlated with Adiponectin（P〈0.01）.Conclusion C-reactive protein,adiponectin and insulin resistance in hypertensive patients is correlated with carotid atherosclerosis.