卒中后抑郁患者生活质量研究

Study on the quality of life of post-stroke depression patients

目的研究影响卒中后抑郁患者生活质量的相关因素,探讨抑郁好转程度、神经功能恢复与生活质量改善的相关性。方法收集急性脑卒中并发抑郁的病例70例,调查患者的一般临床资料包括患者的年龄、性别、婚姻、职业、性格、学历、居住地、月经济收入、社会支持、家庭关系、卒中类型、卒中次数、颈动脉狭窄、合并症(高血压、糖尿病、心脏病、血脂代谢紊乱),并进行Hamilton抑郁量表-21项、社会支持评定量表、中国脑卒中临床神经功能缺损程度评分量表评分、中风病患者生存质量量表(QOLIS 1.0版)评分。结果①经多元逐步回归分析得出,抑郁程度、神经功能缺损、职业、性格、卒中次数、年龄对卒中后抑郁患者生活质量的影响有统计学意义。②卒中后抑郁患者经治疗后抑郁好转程度、神经功能恢复与生活质量改善有相关性。结论①降低卒中后抑郁患者生活质量的相关因素有抑郁程度严重、神经功能缺损严重、劳动、内向、卒中次数多、年龄大。②抑郁好转程度越明显,神经功能恢复越好,生活质量提高越大。

Objective To explore the influential factors of the quality of life of post-stroke patients,and the correlation of neural function recovery and the improvement of the depression with the improvement of quality of life after the antidepressant therapy.Methods The clinical data of 70 patients suffering from acute stroke with depression,such as age,gender,marital status,career,character,education,inhabited area,income per month,social support,family relationship,stroke pattern,stroke times,carotid artery stenosis,and accompanyied diseases（high blood pressure,diabetes,heart disease,and lipid metabolism disorder）were investigated.The Hamilton depression rating scales-21,social support rating scales,Chinese stroke clinical nerve deficiency scales and quality of instruments for stroke patients（QOLISP 1.0） were used to evaluate all patients.Results ①The multiple stepwise regression analysis showed that the depression level,neurological deficit,career,character,stroke time and age had statistical influence on quality of life of patients with post-stroke depression.②The degrees of depression improvement and nerve functional rehabilitation were correlated with improvement of quality of life after treatment.Conclusion ①The severity of depression and neurological deficit,labor,introversion,more stroke times and the older would be the risk factors for quality of life of post-stroke depression patients.②Improvement of quality of life would be higher when the degree of depression improvement is higher and nerve functional rehabilitation is better.