非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者的鼻通气功能评估

Assessment of Nasal Ventilation Function of Nonallergic Rhinitis with Eosinophilia Syndrome

目的本文检测非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者(nonallergic rhinitis with eosinophilia syndrome,NARES)的鼻通气功能,分析其与主观症状的相关性。方法 NARES患者22例,健康成人58例。测量鼻阻力获得压力-流速曲线,得到75Pa和150Pa下鼻腔总阻力值。测量使用1%麻黄碱滴鼻液前后鼻腔的鼻声反射,获得相应的面积-距离曲线,得到鼻腔最小横截面积,计算鼻腔充血指数。分析非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者症状评分与鼻通气功能指标间的相关性;对比NARES组与对照组鼻阻力和鼻声反射测量各项指标。结果 ①NARES患者鼻阻力、鼻声反射指标与各鼻部症状间的相关性分析差异均无统计学意义;②鼻声反射仪测量收缩前后的鼻腔最小横截面积以及鼻腔充血指数,NARES组与正常对照组相比差异无统计学意义;③NARES组与正常对照组相比,收缩前75Pa和150Pa下鼻总阻力值差异有统计学意义,收缩后75Pa和150Pa下的鼻总阻力值差异无统计学意义。结论 NARES患者主观症状与客观鼻生理功能检测结果间无相关性,在诊疗过程中需全面综合评价患者的主观症状和客观检测结果。

Objective：To measure the nasal patency of patients with nonallergic rhinitis with eosinophilia syndrome（NARES） and healthy controls and to assess its correlation with visual analogue scale（VAS） of nasal symptom.Methods：A total of 22 patients with NARES and 58 healthy controls were studied.By using nasal rhinomanometry,we measured the pressure-flow curve and got total nasal resistances of 75 Pa and 150 Pa.By means of acoustic rhinometry,we obtained the area-distance curve before and after using nasal vasoconstrictive agent,got the nasal minimum cross-sectional area（MCA）,then calculated nasal congestion index（NCI）.We compared the outcomes with nasal resistance and acoustic rhinometry in two groups,evaluated the correlation between VAS and nasal patency of NARES.Results：The correlation between the outcomes with nasal resistance and acoustic rhinometry and VAS of nasal symptom showed no statistical significance in NARES patients.MCA before and after decongestion and NCI showed no statistically significant differences in two groups.Before decongestion,nasal resistance of 75 Pa and 150 Pa had significant differences in two groups,after decongestion showed no significant difference.Conclusion：Nonallergic rhinitis with eosinophilia syndrome is one of the most common nonallergic rhinitis,subjective symptoms had no correlation with objective nasal patency tests.In clinic,it required comprehensive evaluation with subjective symptoms and objective test results of patient.