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前列腺癌中TMPRSS2-ETS基因融合及机制研究进展 被引量：3

The progress of TMPRSS2-ETS gene fusions and their mechanism in prostate cancer
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摘要 超过50%的前列腺癌中存在跨膜丝氨酸蛋白酶2(TMPRSS2)和E26(ETS)转录因子间的基因融合,其中TMPRSS2-ERG最为常见。TMPRSS2-ERG基因融合造成的ERG过表达参与了前列腺的癌变。雄激素受体结合和遗传毒性胁迫共同诱导了染色体的靠近和TMPRSS2-ETS的基因融合。TMPRSS2-ERG基因融合可作为前列腺癌诊断的一种生物标志物,并可通过病人尿液检测来实现。文章对TMPRSS2-ETS基因融合的特征、融合及致癌及临床应用进行了综述。 The gene fusions between transmembrane protease serine 2 （TMPRSS2） and E26 （ETS） transcription factors are present in over 50% of patients with prostate cancer. TMPRSS2-ERG is the most common gene fusion type. The ERG overexpression induced by TMPRSS2-ERG gene fusion contributes to the development of prostate cancer. Both androgen receptor binding and genotoxic stress induce chromosomal proximity and TMPRSS2-ETS gene fusions. TMPRSS2-ERG gene fusion functions as a biomarker for prostate cancer, which can be easily detected in urine. This review focuses on the characteristics, oncogenic and rearranged mechanism, and clinical application of TMPRSS2-ETS gene fusions.
作者 郭晓强 桂耀庭 蔡志明
机构地区 北京大学深圳医院 解放军白求恩军医学院生化教研室
出处 《遗传》 CAS CSCD 北大核心 2011年第2期117-122,共6页 Hereditas（Beijing)
基金 深圳市重点实验室提升计划项目(编号:CXB200903090055A)资助
关键词 前列腺癌 基因融合 跨膜丝氨酸蛋白酶2 E26 融合机制 prostate cancer gene fusion transmembrane protease serine 2 （TMPRSS2） E26 rearranged mechanism
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献31

  • 1De Val S,Black BL.Transcriptional control of endothelial cell development.Dev Cell,2009,16(2):180-195.
  • 2Afar DE,Vivanco I,Hubert RS,Kuo J,Chen E,Saffran DC,Raitano AB,Jakobovits A.Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.Cancer Res,2001,61(4):1686-1692.
  • 3Vaarala MH,Porvari K,Kyll6nen A,Lukkarinen O,Vihko P.The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients:detection of mutated TMPRSS2 form in a case of aggressive disease.Int J Cancer,2001,94(5):705-710.
  • 4Lin B,Ferguson C,White JT,Wang S,Vessella R,True LD,Hood L,Nelson PS.Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.CancerRes,1999,59(17):4180-4184.
  • 5Tu JJ,Rohan S,Kao J,Kitabayashi N,Mathew S,Chen YT.Gene fusions between TMPRSS2 and ETS family genes in prostate cancer:frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.ModPathol,2007,20(9):921-928.
  • 6Winnes M,Lissbrant E,Damber JE,Stenman G.Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer.Oncol Rep,2007,17(5):1033-1036.
  • 7Tomlins SA,Mehra R,Rhodes DR,Smith LR,Rouiston D,Helgeson BE,Cao XH,Wei JT,Rubin MA,Shah RB,Chinnaiyan AM.TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.Cancer Res,2006,66(7):3396-3400.
  • 8孙其鹏,庞俊,李辽源,周祥福,邱剑光,温星桥,高新.荧光原位杂交技术在前列腺癌诊断中的临床应用[J].中华腔镜泌尿外科杂志（电子版）,2010,4(1):54-57. 被引量：7
  • 9戴美洁,陈俐丽,郑彦博,陈伟,陶志华,翁志梁,吴秀玲,李澄棣,陈占国,陈晓东,石少波.前列腺癌组织中TMPRSS2基因与ETS家族基因的多种融合亚型及其意义[J].中华医学杂志,2008,88(10):669-673. 被引量：8
  • 10Hessels D,Smit FP,Verhaegh GW,Witjes JA,Cornel EB,Schalken JA.Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer.Clin Cancer Res,2007,13(17):5103-5108.

二级参考文献56

  • 1那彦群,李鸣.重视前列腺癌诊治规范化研究[J].中华医学杂志,2005,85(45):3169-3169. 被引量：21
  • 2Tomlins SA, Rhodes DR, Pemer S, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science, 2005,310:644-648.
  • 3Tomlins SA, Mehra R, Rhodes DR, et al. TMPRSS2 :ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res, 2006,66:3396-3400.
  • 4Soller MJ, Isaksson M, Elfving P, et al. Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer. Genes Chromosomes Cancer, 2006,45:717-719.
  • 5Egevad L, Granfors T, Karlberg L, et al. Prognostic value of the Gleason score in prostate cancer. BJU Int,2002,89:538-542.
  • 6Winnes M, Lissbrant E, Damber JE, et al. Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncol Rep, 2007,17 : 1033-1036.
  • 7Clark J, Merson S, Jhavar S, et al. Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene, 2007,26: 2667 -2673.
  • 8Hermans KG, van Marion R, van Dekken H, et al. TMPRSS2: ERG fusion by translocatlon or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negatlve prostate cancer. Cancer Res, 2006,66 : 10658-10663.
  • 9Rajput AB, Miller MA, De Luca A, et al. Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers. J Clin Pathol, 2007, 60 : 1238-1243.
  • 10Tu JJ, Rohan S, Kao J, et al. Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod Pathol, 2007,20:921-928.

共引文献23

同被引文献26

  • 1Milan Kral, Vlasta Rosinska, Vladimir Student, et al. Genetic de- terminants of prostate cancer :a review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub ,2011,155 1 ) : 3 - 10.
  • 2Greenlee RT, Murray T, Thun M, et al. Cancer statistics. CA Canc- er J Clin,2001,51:15 -36.
  • 3Spitz MR, Currier RD, Fueger JJ, et al. Familial patterns of prostare cancer : a ease - control analysis. J Urol, 1991,146 ( 5 ) : 1305 - 1307.
  • 4Carter BS, Bova GS, Beaty TH, et al. Hereditary prostate cancer: epidemiologic and clinical features. J Urol, 1993,150 ( 3 ) :797 - 802.
  • 5Lucas JM, True L, Hawley S, et al. The androgen - regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocareinoma. J Pathol, 2008, 215 (2) : 118- 125.
  • 6De Val S, Black BL. Transcriptional control of endothelial cell de- velopment. Dev Cell, 2009, 16(2) : 180 - 195.
  • 7Tomlins SA. Rhodes DR, Pemer S. et al. Recurrent fusion of TM- PRSS2 and ETS transcription factor genes in prostate cancer. Sci- encec, 2005,310:644 - 648.
  • 8Mani RS, Tomlins SA, Callahan K, et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science, 2009, 326(5957) : 1230 - 1245.
  • 9Tomlins SA, Mehra R, Rhodes DR, et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res, 2006, 66(7) : 3396 -3400.
  • 10SoUer MJ, Is aksson M, Elfving P, et al. Confirmation of the high frequency of the TMPRSS2/ ERG fusion gene in prostate cancer. Genes Chromosomes Cancer,2006,45:717 - 719.

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