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国产胆道金属支架联合抗肿瘤治疗胆管癌的疗效分析 被引量:7

The Clinical Efficacy of Domestic Biliary Metallic Stents in the Management of Bile Duct Cancer Combined with Different Anti-cancer Treatments
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摘要 目的探讨国产胆道金属支架联合抗肿瘤治疗胆管癌的疗效。资料与方法回顾性分析35例因胆管癌行国产胆道金属支架置入并联合抗肿瘤治疗的患者临床资料(治疗组)并与38例仅单纯行金属支架治疗者(对照组)行随机对照研究,观察其疗效。结果在生存时间和支架的通畅时间方面联合抗肿瘤组较对照组均明显延长,差异有统计学意义(χ2=12.141,P=0.000<0.05;χ2=12.792,P=0.000<0.05)。在联合抗肿瘤组中17例采取立体照射治疗,15例采取化疗,3例采取立体照射+化疗方式行后续抗肿瘤治疗。三种不同抗肿瘤方法分别与对照组比较,生存时间和支架通畅时间均明显延长,差异有统计学意义(P<0.05)。但治疗组组间生存时间和支架通畅时间差异均无统计学意义(χ2=1.092,P=0.579>0.05;χ2=0.517,P=0.772>0.05)。结论国产胆道金属支架联合抗肿瘤治疗能显著延长患者生存时间和支架通畅时间,是治疗胆管癌的有效方法。 Objective To evaluate the clinical efficacy of domestic biliary metallic stents in the management of bile duct cancer combined with different anti-cancer treatments.Materials and Methods Clinic data of 35 bile duct cancer patients that taken both stenting and anti-cancer treatment and 38 patients that only taken single stenting were analyzed and compared to see if there were difference in clinical efficacy between the two groups.Results There was significant difference in survival rate and stent patency rate between the group of combined with different anti-cancer treatments and group of simple stenting(χ^2=12.141,P=0.0000.05;χ^2=12.792,P=0.0000.05).17 patients received three-dimensional radiation therapy,15 patients received chemotherapy and 3 patients were combined with both three-dimensional radiation therapy and chemotherapy.Comparing with the single stenting group,each of the three groups had significant difference in survival rate and stent patency rate (P〈0.05).But there were no significant differences in survival rate and stent patency rate during the three groups(χ^2=1.092,P=0.5790.05;χ^2=0.517,P=0.7720.05).Conclusion The domestic biliary metallic stent insertion combined with different anti-cancer treatments can increase survival rate and stent patency rate in the patients with bile duct cancer,it is a safe and effective therapy method.
出处 《临床放射学杂志》 CSCD 北大核心 2011年第2期252-255,共4页 Journal of Clinical Radiology
关键词 胆管癌 联合抗肿瘤治疗 金属支架 Cholangiocarcinoma Anti-cancer treatment Metallic stent
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