胃泌素受体拮抗剂抑制胰腺癌细胞生长的初步研究

Proliferation Inhibition Effect of Gastrin Receptor Antagonist on Pancreatic Adenocacinoma Cells

目的探讨应用胃泌素受体拮抗剂治疗胰腺癌的可行性。方法在体外条件下观察胃泌素及其受体拮抗剂丙谷胺对胰腺癌细胞株的细胞活力及细胞增殖的影响。结果在体外条件下,胃泌素能促进胰腺癌细胞株的增殖,而丙谷胺能完全阻断胃泌素的作用。结论胃泌素受体拮抗剂能够抑制胃泌素受体阳性的胰腺癌细胞生长,有望为胰腺癌的治疗提供一种新手段。

Objective To explore the feasibility of gastrin receptor antagonist application in the management of pancreatic adenocacinoma.Methods The viability and proliferation of pancreatic adenocacinoma cell line treated with gastrin and its receptor antagonist proglumide were observed in vitro.Results The proliferation of pancreatic adenocacinoma cell line cells were promoted by the gastrin,while were totally blocked by proglumide.Conclusion Gastrin receptor antagonist could inhibit the growth of gastrin-receptor positive pancreatic adenocacinoma cells,indicating a new possible therapeutic method.