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Th22细胞在自身免疫性疾病中的作用 被引量：1

Roles of Th22 cells in autoinnune diseases
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摘要 Th122细胞亚群是近年来新发现的一类CD4＋细胞亚群,主要分泌白介素-22、白介素-13、白介素-26等细胞因子,而不产生干扰素-γ和白介素-4.其功能主要通过白介素-22来实现,可介导炎症反应、自身免疫性疾病、肿瘤等,在机体免疫调节、宿主防御及组织修复中发挥重要作用.最重要的是,Th22细胞还能参与细胞增生、分化及凋亡的调节过程.研究表明,多种自身免疫性疾病的白介素-22表达异常,提示Th22细胞与T细胞介导的自身免疫性疾病有关. Th22 cells are a new subset of CD4＋ T cells identified in recent years. They mainly secrete interleukin （IL）-22, IL-13 and IL-26, but not interferon-γ （IFN-γ） or IL-4, and exert their function mainly via IL-22. They can mediate inflammatory reactions, autoimmune diseases, tumors, etc, and play an important role in immune regulation, host defense and tissue repair. Most importantly, Th22 cells can modulate cell proliferation, differentiation and apoptosis. Studies have shown an abnormal expression of IL-22 in a variety of autoimmune diseases, hinting that Th22 cells are involved in T cell-mediated autoimmune diseases.
作者 顾俊瑛 史玉玲
机构地区 同济大学附属上海市第十人民医院皮肤性病科
出处 《国际皮肤性病学杂志》 2011年第2期84-87,共4页 International Journal of Dermatology and Venereology
基金 基金项目：上海市科委基金（09411960600）
关键词 TH22细胞 白细胞介素22 自身免疫疾病 Th22 cells Interleukin-22 Autoimmune diseases
分类号 R593 [医药卫生—内科学]
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参考文献27

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二级参考文献69

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国际皮肤性病学杂志
2011年 第2期

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