Th17细胞与HIV感染的关系

T helper 17 （Th17） cells and HIV infection

来源于初始T细胞的Th17细胞是新发现的一类不同于Th1、Th2的CD4＋T细胞,其分泌IL-17、IL-6、IL-22和肿瘤坏死因子等细胞因子,在介导慢性炎症反应、自身免疫性疾病等方面发挥着重要作用.研究表明,IL-17在HIV感染中发挥着抗感染作用,同时在抗HIV细胞因子调控网络中,IL-17也起着重要作用.在HIV感染早期,Th17细胞在外周血液及胃肠道中大量减少甚至衰竭,但是Th17能否发挥抗病毒功能还需要更深入探究.研究已证明,病毒首先攻击的靶点细胞是CCR5＋CCR6＋Th17.Th17作为HIV新的靶向细胞,有望为艾滋病提供新的治疗策略.

Th17 cells that derive from initial T cells are a newly discovered class of CD4＋ T cells different from Th1 and Th2 cells. They secrete interleukin （IL）-17, IL-6, IL-22, tumor necrosis factor and other cytokines, and play an important role in mediating chronic inflammation, autoimmune diseases, etc. Recent studies have evidenced that IL-17 posseses a potent anti-HIV activity and exerts a crucial role in anti-HIV cytokine regulatory networks. In early HIV infection, there is a significant reduction or depletion of Th17 cells in peripheral blood and gastrointestinal tract. Nevertheless, further exploration is required to clarify the antiviral function of Th17 cells. Studies have evidenced that the first target of HIV virus attacks is CCR5＋CCR6＋Th17 cells. As a new target of HIV, Th17 cells are expected to provide new therapeutic strategy for AIDS treatment.