抗结核药肝脏毒性与脂质过氧化及抗氧化的关系

Relationship between Hepatic Injury and Peroxidation Induced by Anti-Tuberculosis Agents

目的:探讨抗结核药物所致肝脏毒性与脂质过氧化的关系.方法:以经抗结核药物治疗后发生肝脏损害的肺结核病人为研究对象,以血清过氧化脂质(LPO)、超氧化物歧化酶(SOD)和还原型谷胱甘肽(GSH)为指标,观察肝损害脂质过氧化及抗氧化的关系.结果:有肝脏损害病人的血清脂质过氧化水平明显高于对照组,而血清超氧化物歧化酶和还原型谷胱甘肽显著低于对照组.结论:由抗结核药物所引起的肝脏损害与体内的脂质过氧化有关,且会消耗体内的抗氧化物质.

To study the relationship between hepatic injury and lipid peroxidation or anti-peroxida-tion or anti-oxidation induced by anti-tuberculosis agents, serum LPO, SOD and GSH were examined in the tuberculosis patients suffering from hepatic injury induced by anti-tuberculosis and those without hepatic injury after treatment. Serum LPO in the patients with hepatic injury was significantly higher than those without hepatic injury. Serum GSH in the patients with hepatic injury was significantly lower than those withouthepatic injury. A significant correlation between liver functions and GSH was observed in patients with hepatic injury.