摘要
以具有活血化瘀作用的中药有效成分阿魏酸为先导物,设计合成了6个阿魏酸衍生物,其结构经IR、1H NMR、13C NMR及MS确证。体内药效筛选结果显示,阿魏酸衍生物对二磷酸腺苷(ADP)诱导的血小板聚集具有较好的抑制活性,其抑制作用明显强于阳性对照药奥扎格雷钠。
Ferulic acid,an useful compound of Chinese traditional medicine,was used as leading compound.Six ferulic acid derivatives were designed and synthesized based on bioisosterism.Their structures were characterized by IR,1H NMR,13C NMR and mass spectra.In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate(ADP) induced platelet aggregation,which were significantly higher than that of Ozagrel.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第3期305-310,共6页
Acta Pharmaceutica Sinica
基金
国家"重大新药创制"科技重大专项资助项目(2009ZX09103-123)
安徽高校省级自然科学研究重点项目(KJ2010A206)
关键词
阿魏酸
阿魏酸衍生物
血栓
抗血小板聚集
ferulic acid
ferulic acid derivatives
thrombosis
platelet aggregation inhibition