肝硬化合并自发性细菌性腹膜炎预后影响因素分析

A retrospective analysis of the factors influencing the prognosis of liver cirrhosis combined with spontaneous bacterial peritonitis

目的探讨肝硬化合并自发性细菌性腹膜炎(SBP)预后的影响因素。方法回顾性分析135例肝硬化合并SBP患者的临床资料,根据其预后分为存活组(88例)与死亡组(47例),比较两组病例年龄、性别、既往SBP史、症状与体征、Child-Pugh分值、外周血和腹水中白细胞数、并发症、重要生化指标等因素。结果两组病例在年龄、既往SBP史、腹部多数症状及其它(呃逆、黄疸加深、休克)、Child-Pugh评分、外周血中性粒细胞比例、腹水白细胞数及多核粒细胞(PMN)比例、多数并发症及发生并发症个数、重要生化指标间差异均有统计学意义(P<0.05,P<0.01)。结论年龄、既往SBP史、多数症状与体征、Child-Pugh评分、外周血中性粒细胞比例、腹水白细胞数及多核粒细胞(PMN)比例、重要生化指标及并发症等因素均影响肝硬化并SBP患者转归,可作为评价此病预后的重要指标。

Objective To explore the factors influencing the prognosis of liver cirrhosis combined with spontaneous bacterial peritonitis（SBP）.Methods Clinical data of 135 patients with cirrhosis combined with SBP were analyzed retrospectively.Cases were divided into alive group（n=88） and dead group（n=47） according to their prognosis.Age,sex,past history of SBP,symptoms and signs,Child-Pugh score,leucocyte in peripheral blood and ascites,complications and important biochemical indicators of the two groups were compared.Results There were significant statistical differences in age,past history of SBP,abdominal symptoms and others（hiccup,deepened jaundice and shock）,Child-Pugh score,blood neutrophil proportion,leucocyte and polymorphonuclear（PMN） cells in ascites,complications,and important biochemical indicators（P0.05,P0.01） between the two groups.Conclusion Age,past history of SBP,most symptoms and signs,Child-Pugh score,blood neutrophil proportion,leucocyte and polymorphonuclear（PMN） cells in ascite,important biochemical indicators and complications can influence the survival rate of cirrhosis combined with SBP and be used as an important indicators to determine the prognosis of the disease.