冠心病并发抑郁与血清白介素-6水平的关系

Relationship of serum interleukin-6 level with coronary heart disease accompanied by depression

目的:分析冠心病(CHD)患者的心理状况,探讨血清白介素-6(IL-6)与CHD并发抑郁的关系,为临床提供CHD并发抑郁干预治疗的依据。方法:对90例CHD患者进行ZUNG抑郁自评量表(SDS)评分,根据评分结果分为CHD伴有抑郁组(A组)与不伴抑郁组(B组)。用放射免疫法测定血清IL-6的水平,并记录年龄、性别、吸烟、文化程度、糖尿病、高血压病史及血脂水平等相关资料。结果:入选的CHD患者57.58%伴有不同程度的抑郁,其中轻度抑郁者24例(26.67%),中、重度抑郁者28例(31.11%)。男性患者57.79%伴有抑郁,女性患者57.89%伴有抑郁;男、女性CHD患者抑郁并存率之间的差异无统计学意义。A组患者血清IL-6的水平[M(P25,P75]为[0.04(0.01,0.06)]μg/L,B组患者为[0.02(0.01,0.05)]μg/L,A组高于B组,差异有统计学意义(P<0.05)。A组中、重度抑郁患者血清IL-6水平为[0.05(0.02,0.08)]μg/L高于轻度抑郁IL-6水平为[0.04(0.01,0.05)]μg/L,差异有统计学意义(P<0.05)。结论:CHD患者有较高的抑郁并存率,CHD伴有抑郁患者血清IL-6的水平明显高于不伴有抑郁患者,中、重度抑郁患者血清IL-6的水平明显高于轻度抑郁。CHD伴有抑郁是体内具有炎性反应的一个标志,也即炎性反应在CHD并发抑郁中起着一定的作用。

AIM： To explore the relationship between interleukin-6（IL-6） and coronary heart disease（CHD） combined with depression for intervention strategies.METHODS： Ninety patients with CHD were recruited into the study and,according to ZUNG self-depression scale（SDS） scores,were divided into two groups： CHD combined with depression（group A） and CHD without depression（group B）.Serum levels of IL-6 were measured by radioimmunoassay and personal data including age,gender,smoking habit,educational level,diabetes and hypertension history,and lipid levels were collected.RESULTS： It was found that 57.78% of the patients had varying degrees of depression,of whom 24（26.67%） had mild depression and 28（31.11%） had moderate and severe depression.Depression was found in 57.59% of the male patients and in 57.89% of female patients,with no statistical difference in the concomitance rate of depression between genders（P〈0.05）.Levels of serum IL-6 [M（P25,P75）] in group A [0.04（0.01,0.06）] μg/L were significantly higher than in group B [0.02（0.01,0.05）] μg/L（P〈0.05）.In group A,the levels of serum IL-6 in patients with moderate and severe depression [0.05（0.02,0.08）] μg/L were higher than those in patients with mild depression [0.04（0.01,0.05）] μg/L（P〈0.05）.CONCLUSION： CHD patients with depression have a high concomitance rate.The level of IL-6 in CHD patients with depression is higher than in CHD patients without depression.In patients with moderate and severe depression the levels were higher than those in patients with mild depression.CHD combined with depression is a sign of activation of inflammatory responses.Inflammatory responses play a role in CHD combined with depression.