6～12岁双生女童头影测量中切牙位置遗传作用的纵向分析

Longitudinal genetic effect on incisor position in cephalograms of female twins from six to twelve years old

目的:明确遗传和环境因素在生长发育过程中对颅面形态的影响。方法:测量89对双生子女童的头颅侧位片。采用混合纵向观察法,最终得到有效双生子对数183对(其中同卵110对,异卵73对)。利用双生子法对切牙位置做遗传和环境作用的纵向统计学分析,采用SPSS13.0软件包对数据进行独立样本t检验。结果:6个切牙位置关系均有显著环境因素作用(P<0.05),角度LI-MP有显著家族遗传因素作用(P<0.05)。结论:单纯的牙位置关系受遗传因素的影响较弱,但遗传对切牙位置的影响需予以重视。

PURPOSE： A better understanding of the relative effect of genes and environment on craniofacial parameters should improve the possibilities and limitations of the orthodontic treatment and treatment planning.This is especially important for early treatment started in the mixed dentitions that is performed to enhance the dental and skeletal development before the eruption of the permanent dentition.METHODS： The sample used in this study consisted of lateral cephalograms of eighty-nine pairs of female twins in Beijing.With a mixed longitudinal method,the effective twins were 183 pairs（MZ 110,DZ 73）.With the statistical methods of twins,the genetic and environmental effects were analyzed on the position of incisors in female twins from six to twelve years old.SPSS13.0 software package was used for independent-sample t test.RESULTS： Statistical comparisons revealed significant environmental effects on 6 positions of incisors（P﹤0.05）,whilst family genetic effects on angle LI-MP were significant（P﹤0.05）.CONCLUSION： Although the relatively low inherited proportions of dental variations could be found,genetic effects on incisor position should be carefully treated.