摘要
目的:测定尼美舒利在兔体内药物代谢动力学过程,比较片剂、混悬剂、栓剂的药动学参数。方法:用高效液相色谱法测定血浆中尼美舒利浓度,用3P87程序处理血药浓度数据。结果:片剂与混悬剂的药动学参数无显著性差异(P>0.05),栓剂的T_(max)、t1/2ke明显长于片剂和混悬剂,相对于片剂的生物利用度为79.9％,相对于混悬剂的生物利用度为74.5％。
Objective: To study the pharmacokinetics properties and pharmacokinetic parameters of nimesulide in tablet, suspension, and suppository. Method: The plasma concentration of nimesulide was determined by HPLC. the data was treated with 3p87 procdeure. Result: There was a significant difference in the pharmacokinetics parameters between ninesulide tablet and nime-sulid suspension. tmax, t1/2ke of suppository were longer than that of tablet and suspension. The bioavailability of suppository to tablet was 79.9 % and to suspension 74.5 % .
出处
《中国药师》
CAS
1999年第4期173-174,共2页
China Pharmacist
关键词
尼美舒利
片剂
混悬剂
栓剂
药代动力学
Nimesulide
Tablet
Suspension
Suppository
Pharmacokinetics
Bioavailability
