狗注入尖吻蝮类凝血酶后纤维蛋白(元)降解产物对血凝的影响

EFFECT OF FIBRIN(OGEN)DEGRADATION PRODUCTSON BLOOD COAGULATION FOLLOWING THEINTRAVENOUS INFUSION OF AAV-TLE IN DOGS

目的：观察狗注入尖吻蝮蛇毒类血酶（ＡＡＶ－ＴＬＥ）后，血清纤维蛋白（元）降解产物对血液凝固的影响。方法：将ＡＡＶ－ＴＬＥ静脉注入狗体内，分别测定凝血活酶时间（ＫＰＴＴ）、凝血酶元时间（ＰＴ）以及血浆纤维蛋白原（Ｆｇｎ）和血清纤维蛋白（元）降解产物（ＦＤＰ）含量。结果：ＫＰＴＴ和ＰＴ明显延长；血清ＦＤＰ显著增加；血浆Ｆｇｎ含量大幅度下降。结论：狗注入ＡＡＶ－ＴＬＥ后，ＫＰＴＴ和ＰＴ延长除与血浆Ｆｇｎ下降有关外，ＦＤＰ的增加是主要原因。

OBJECTIVE: To study the effect of FDP on blood coagulation following the intravenous infusion of AAV-TLE into anesthetized dogs. METHOD: The blood sample,which was drawn from a surgically exposed femoral artery of dog and put into a siliconized tube containing anticoagulant solution before and after intravenous injection of AAV-TLE(5 g/kg),was used for FgnKPTTPT and FDP determinations. RESULTS: It was observed that the AAV-TLE caused a pronounced prolongation of KPTT and PT tests,a marked elevation of serum FDP Level and a significant decrease of plasma Fgn level. CONCLUSION: In addition to the decrease of plasma Fgn level,the prolongation of KPTT and PT tests mainly is induced by inhibition of clotting function which is attributalbe to increasing serum FDP levels.