石墨炉原子吸收法测定盐酸伐昔洛韦中钯的残留量

Palladium Residues Determination in Valaciclovir Hydrochloride by Graphite Furnace Atomic Absorption Spectrometry

目的建立盐酸伐昔洛韦中钯残留量的测定方法。方法采用微波消解系统消解样品，石墨炉原子吸收分光光度法测定盐酸伐昔洛韦中钯的残留量。结果钯在浓度1．0-30．0ug·L-1内呈良好线性关系（r=0．9995）。检出限为0．20ug·L-1，定量限为0．95ug·L-1，特征浓度（灵敏度）为0．57ug·L-1，平均回收率为101．69％。结论采用本法测定盐酸伐昔洛韦中钯的残留量灵敏、准确、可靠，为药品质量控制提供依据。

OBJECTIVE To establish a method for the determination of Pd in valaciclovir hydrochloride. METHODS Appling microwave degrading system to deteriorate sample, use a graphite furnace atomic absorption spectrometry （AAS） method to determine Pd residues in valaciclovir hydrochloride. RESULTS It showed a good linear relationship within the concentration range of 1.0-30.0ug·L-1（r=0.999 5）. The LOD and LOQ were 0.20 ug·L-1 and 0.95 ug·L-1, respectively. The characteristic concentration （sensitivity） was 0.57 ug·L-1 and the average recovery was 101.69%. CONCLUSION This method is sensitive, accurate and reliable to control the residues of Pd in valaciclovir hydrochloride, providing the basis for drug quality control.