摘要
目的建立盐酸伐昔洛韦中钯残留量的测定方法。方法采用微波消解系统消解样品,石墨炉原子吸收分光光度法测定盐酸伐昔洛韦中钯的残留量。结果钯在浓度1.0-30.0ug·L-1内呈良好线性关系(r=0.9995)。检出限为0.20ug·L-1,定量限为0.95ug·L-1,特征浓度(灵敏度)为0.57ug·L-1,平均回收率为101.69%。结论采用本法测定盐酸伐昔洛韦中钯的残留量灵敏、准确、可靠,为药品质量控制提供依据。
OBJECTIVE To establish a method for the determination of Pd in valaciclovir hydrochloride. METHODS Appling microwave degrading system to deteriorate sample, use a graphite furnace atomic absorption spectrometry (AAS) method to determine Pd residues in valaciclovir hydrochloride. RESULTS It showed a good linear relationship within the concentration range of 1.0-30.0ug·L-1(r=0.999 5). The LOD and LOQ were 0.20 ug·L-1 and 0.95 ug·L-1, respectively. The characteristic concentration (sensitivity) was 0.57 ug·L-1 and the average recovery was 101.69%. CONCLUSION This method is sensitive, accurate and reliable to control the residues of Pd in valaciclovir hydrochloride, providing the basis for drug quality control.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2011年第3期260-262,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
石墨炉原子吸收分光光度法
钯
盐酸伐昔洛韦
graphite furnace atomic absorption spectrometry
palladium
valaciclovir hydrochloride