肝内型微小肝癌B超引导切肝术及DNA含量研究

Hepatectomy for endohepatic microcancer guided by intraopertive B-ultrasonographic locating and DNA content of tumor

目的探讨肝内型微小肝癌术中Ｂ超快速定位，ＤＮＡ含量分析对判断预后的意义。方法利用术中Ｂ超肝癌低回声特征而定位。应用细胞图像分析来测定肝癌、肝硬化、正常肝的ＤＮＡ含量及倍体。结果本组２２例术中Ｂ超定位准确、手术切除疗效好，５年生存率达６８％，ＤＮＡ倍体２Ｃ含量顺序为正常肝＞肝硬化＞肝癌。结论术中Ｂ超不但能快速定位且能了解肿瘤与肝内主要血管关系，指导切肝具有一定优越性。ＤＮＡ倍体测定结果说明微小肝癌易变性轻、分化程度好、预后佳。

Objective To study the value of intraoperative B-ultrasongraphy and DNA content determina-tion of tumor in rapidly locating endohepatic microcancer and predicting prognosis. Methods Locating turmor byits characteristic low-echo reflection by B-ultrasonography during operation and determinating DNA content of can-cerous, cirrhotic and normal liver tissues by image analysis. Results in 22 cases of this series accurate locatingin operation and excellent curative effect were all achieved. The 5-year survival rate was 68%. Diploid DNA con- tents in various tissues the following decreasing order: normal liver, cirrhaic liver, cancerous tissues.Conclusion B-ultrasonography used in operation not only locates tumor quickly but is also indicative for uder-standing anatomic relationship between tumor and major vessels in liver. It is somewhat advantegeous for hepatecto-my. Diploid DNA content determination is valuable for prognosis: the higher, the better.