摘要
目的研究葛根素自微乳对大鼠肠吸收的改善作用。方法以离体大鼠外翻肠囊模型研究葛根素自微乳的肠吸收部位和促吸收效果,采用HPLC测定样品浓度,计算累计吸收率。结果葛根素自微乳在各肠段的累计吸收率比较依次为:回肠>空肠>十二指肠>结肠;葛根素自微乳的累计吸收率显著高于葛根素混悬液。结论葛根素自微乳最佳吸收部位为小肠中后段,尤其是回肠;与葛根素混悬液相比,葛根素自微乳能够显著改善肠吸收。
Objective To investigate rat intestinal absorption efficiency of puerarin self-microemulsion.Methods The isolated everted gut model was used to investigate the absorption sites and absorption efficiency of puerarin self-microemulsion in rats,the concentration of puerarin in the samples was detected by HPLC and its accumulative absorption rate was calculated.Results The accumulative absorption rate of puerarin self-microemulsion at different segments of rat intestine were as follows： ileum jejunum duodenum colon.The accumulative absorption rate of puerarin self-microemulsion was significantly improved compared with that of puerarin suspension.Conclusion The optimal absorption sites for puerarin self-microemulsion were in the middle and lower intestinal segments of rats,and ileum has the highest rate.The intestinal absorption of puerarin self-microemulsion is superior to that of puerarin suspension.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2011年第2期181-184,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家科技支撑计划项目(2006BA11B08-04)
关键词
葛根素
自微乳
外翻肠囊
肠吸收
Puerarin
Self-microemulsion
Isolated everted gut model
Intestinal absorption
