川崎病患儿血浆NT-proBNP、BNP变化及其临床意义

Clinic Significance and Variation of N-terminal Pro-brain Natriuretic Peptide and Brain Batriuretic Peptide in Children with Kawasaki Disease

目的探讨川崎病(KD)患儿血浆N末端脑利钠肽前体(NT-proBNP)和脑利钠肽(BNP)变化及其意义。方法采用ELISA分别测定51例KD患儿应用IVIG前、后及15例对照儿童(对照组)血浆NT-proBNP和BNP水平。结果 KD组、对照组血浆NT-proBNP、BNP水平差异均具有统计学意义(P<0.05);不完全KD(n=12例)血浆NT-ProBNP水平较对照组患儿明显升高,BNP水平增高不明显。结论血浆BNP和NT-pro BNP可作为早期诊断KD较好的血清学指标。

Objective To explore the change and value of plasma brain natriuretic peptide（BNP） and N-terminal pro-brain natriuretic peptide（NT-proBNP） in children with Kawasaki Disease（KD）. Methods 51 KD patients,aged from 4 months to 75 months,and 15 patients with acute upper respiratory infection as control were enrolled into the experiment.Plasma concentrations of BNP and NT-proBNP were measured by ELISA. Results The levels of plasma NT-pro BNP and BNP were significantly higher in KD patients than those of control group;plasma NT-pro BNP level was significantly higher in iKD than that of control group. Conclusion The data indicated that plasma BNP and NT-pro BNP could be used as useful biochemical markers in diagnosis of KD,and plasma NT-proBNP is more valuable in diagnosis of iKD.