铜绿假单胞菌临床感染及耐药性分析

Clinical Infection of Pseudomonas Aeruginosa and the Analysis of Its Drug Resistance

目的了解铜绿假单胞菌的临床感染特点和耐药性。方法回顾性分析2008年7月至2010年7月江汉大学附属医院临床送检标本中分离出的铜绿假单胞菌的分布情况及药物敏感试验结果。结果分离的103株铜绿假单胞菌主要来源于痰液标本,占74.8%,且主要分布于干部病房和呼吸内科等科室;铜绿假单胞菌对头孢哌酮/舒巴坦的耐药率最低(6.8%),其次是阿米卡星(8.7%);耐药率最高的是左旋氧氟沙星(24.3%)和氨曲南(20.4%)。结论铜绿假单胞菌主要引起呼吸道感染,对临床常用抗菌药物均有不同程度的耐药。

Objective To investigate the infection and drug resistance of clinical pseudomonas aeruginosa and provide reference for the clinical therapy.Methods Retrospectively survey and statistical analysis were carried out in the clinical distribution and antimicrobial susceptibility testing of pseudomonas aeruginosa isolated from Jul 2008 to Jul 2010.Results The separated 103 strains of PA were mainly from sputum,accounting for 74.8%,and mainly distributed in cadre department and respiratory department.The result of antimicrobial susceptibility testing showed that the lowest resistance rate is to sulbactam/cefoperazone（6.8%） and to amikacin（8.7%）;the highest resistance rate is to levofloxacin（24.3%） and to aztreonam（20.4%）.Conclusion Pseudomonas aeruginosa causes mainly respiratory infection,and is highly resistant to some antibiotics.We should strengthen the monitoring of the antibiotic resistance and rational utilization.