糖尿病合并高血压患者不同血压水平与心血管事件的相关性研究

Association of Blood Pressure with Cardiac in Patients with Type 2 Diabetes Mellitus and Essential Hypertension

目的探讨2型糖尿病(T2DM)合并高血压(EH)患者不同血压水平对心血管事件(CVD)的影响。方法收集T2DM合并EH患者2 8 0例,将患者按收缩压(SBP)水平分为>1 4 0 mmHg(1 mmHg=0.1 3 3 kPa)、≤1 4 0 mmHg、SBP≤1 3 0 mmHg、SBP≤120 mmHg 4组,每组70例。分析不同SBP对患者CVD的影响。结果 CVD(非致死性心肌梗死、需住院治疗的心衰或不稳定型心绞痛、冠状动脉血运重建)发病率在SBP>140 mmHg组高于SBP≤140 mmHg、SBP≤130 mmHg、SBP≤120 mmHg组,差别有统计学意义(P<0.05);在SBP≤140 mmHg、SBP≤130 mmHg、SBP≤120 mmHg 3组间比较,差异无统计学意义(P>0.05)。结论降压治疗可降低T2DM合并EH患者CVD发病率,但并非越低越好,SBP≤140 mmHg是一个合适水平。

Objective To explore the influence of blood pressure（BP） on cardiovascular disease events in patients（pts） with type 2 diabetes mellitus（T2DM） and essential hypertension（EH）.Methods An analysis was conducted in 280 pts with T2DM and EH.All pts were divided into systolic blood pressure（SBP）140 mmHg group,SBP≤140 mmHg group,SBP≤130 mmHg group,and SBP≤120 mmHg group.The cardiovascular disease events（nonfatal myocardial,hospitalization for congestive heart failure or unstable angina,coronary revascularization） were studied.Results The incidence of cardiovascular disease events in the SBP140 mmHg group was markedly higher than that in SBP≤140 mmHg group,SBP≤130 mmHg group,and SBP≤120 mmHg group（P0.05）.There were no significant differences between SBP≤140 mmHg group,SBP≤130 mmHg group,and SBP≤120 mmHg（P0.05）.Conclusion Lowing blood pressure could reduce the incidence of cardiovascular disease events in pts with T2DM and EH.