法舒地尔对VEGF诱导肺动脉平滑肌细胞增殖的抑制作用
摘要
肺动脉平滑肌细胞（PASMCs）增殖是肺动脉高压（PAH）中肺动脉重塑的一个重要因素.各种刺激均可促进PASMCs的移行和增殖,导致动脉壁增厚和PAH的形成[1].血管内皮生长因子（VEGF）可以促进PASMCs的增殖[2,3],在严重的PAH发病过程中,VEGF控制着毛细血管前动脉的重构[4].小G蛋白Rho及其效应物Rho激酶（ROCK）信号通路在各种细胞功能中,包括血管平滑肌细胞的收缩和增殖中都起着重要作用.
出处
《中西医结合心脑血管病杂志》
2011年第3期341-343,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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