重组人乳铁蛋白对大鼠生长发育作用的研究

Effect of recombinant human lactoferrin on improving the growth of rats

目的研究从转基因牛乳中分离纯化的重组人乳铁蛋白是否具有促进动物生长发育的作用。方法给大鼠灌胃重组人乳铁蛋白共8周,设低、中、高3个剂量组(0.375、0.75和2.25 g/kg BW.d),以水为对照组。检测指标包括动物体重、身长、摄食量和食物利用率。结果高剂量组体重、身长和食物利用率指标均显著优于对照组,低、中剂量组的体格发育指标较对照组有轻度改善。结论在本研究条件下,重组人乳铁蛋白具有促进大鼠生长发育的作用。

Objective To study whether the growth of rats will be improved by recombinant human lactoferrin（rhLF） separated and purified from transgenic cow milk.Methods rhLF was administered by gavage to 4 groups of 14 male weaned Wistar rats at doses of 0.375,0.75 or 2.25 g/（kg BW.d） for 56 days.Body weight,body length and food consumption were recorded at regular intervals.Results Compared with the control group,the physical parameters including body weight,body length and food utilization were improved obviously in the high dose group.There is a slight improvement on physical parameters in the low and medium dose groups.Conclusion Recombinant human lactoferrin might show a function of improving the growth of rats in this study.