原发性醛固酮增多症的发病机制

Pathogenesis of primary aldosteronism

原发性醛固酮增多症是继发性高血压最常见的原因之一，与具有相同危险程度的原发性高血压患者比较，原发性醛固酮增多症患者心、脑血管及肾脏等靶器官的损伤更为多见。近年来，随着对原发性醛固酮增多症的深入研究，发现其发病机制涉及融合基因的产生、醛固酮合成酶（CYP11β2）基因多态性的改变、肾上腺异位受体的表达及7p21-22基因的改变等。对原发性醛固酮增多症发病机制的研究可能为此病的治疗开辟新的方向。

Primary aldosteronism is one of the most common causes of secondary hypertension. Compared with essential hypertension patients who have same risk factors,impared cardiovascular, cerebrovascular and kidney damage are more prevalent in patients with primary aldosteronism. In recent years ,with the further research of primary aldostcronism, it was shown that the pathogenesis of primary aldosteronism related to CYP11β2 gene polymorphisms, production of hybird gene, expression of ectopic adrenal receptors, 7p21-22 gene and so on. Researches of pathogenesis of primary aldosteronism may provide a novel therapeutic strategy.