佳木斯地区女性泌尿系统感染大肠埃希菌耐药性分析

Identification and drug resistance of Escherichia coli from female urinary infection in Jiamusi area

目的分析女性患者泌尿系统感染大肠埃希菌的耐药性,为临床合理使用抗生素提供依据。方法采用全自动微生物鉴定系统对女性泌尿系统感染患者分离出的病原菌进行鉴定和药敏分析。结果大肠埃希菌非产ESBLs株对氨苄西林、第一、二代头孢菌素类药品高度耐药。大肠埃希菌非产ESBLs株对碳青霉烯类药物美罗培南无耐药,对第三代头孢菌素敏感率高,耐药率低。产ESBLs大肠埃希菌,仅碳青霉烯类抗生素美罗培南敏感。结论女性泌尿系统感染大肠埃希菌的多重耐药性日趋严重,需加强对抗生素使用的规范化管理,合理使用抗菌药物,控制耐药菌的传播和流行。

Objective To analyze drug resistance of Escherichia coli from urinary tract infection in female,and provide reference for clinically rational application of antibiotics. Method Automatic bacterium identifying and drug sensitivity analyzing systems were used to analyse the bacteria isolated from female patients with urinary tract infection. Result E.coli non-ESBLs producing strains were highly resistant to Ampicillin trihydrate and the first or second generation cephalosporin drugs,while sensitive to Carbapenems meropenem and to the third generation cephalosporins.The drug resistance of ESBLs-producing E.coli strains were only sensitive to Carbapenems. Conclusion The drug resistance of Escherichia coli in woman patients with urinary tract infection tend to be more serious.It＇s very important to take effective measurements to control the prevalence of drug resistant bacteria.