慢性乙型重型肝炎预后的危险因素相关性分析

Study the risk factors influencing the prognosis of chronic severe hepatitis B

目的探讨影响慢性乙型重型肝炎患者预后的危险因素。方法收集浙江大学医学院附属第一医院345例慢性乙型重型肝炎患者临床资料,根据治疗结果分为好转组和恶化组,回顾性分析患者9项临床资料与预后间的相关性。结果患者年龄、重叠其他病毒感染、有无合并肝硬化以及是否抗病毒治疗2组间差异有统计学意义(P<0.05),而患者性别、嗜烟酒、并发糖尿病和高血压等因素在2组间差异无统计学意义(P>0.05)。结论年龄较大,重叠其他病毒感染,有肝硬化基础及未经抗毒治疗的慢性乙型重型肝炎患者预后较差。

Objective To study the risk factors influencing the prognosis of chronic severe hepatitis B. Method Three hundreds and forty-five patients with chronic severe hepatitis B were divided into improved group and aggravated group.Nine clinical and laboratory parameters were collected as predictive risk factors.The relationships between risk factors and chronic severe hepatitis B were analyzed retrospectively. Result Some reanses as the ages,co-infection and anti-viral treatment were significant different between the two groups（P〈0.05）.However,the sex,smoking,drinking,diabetes mellitus and hypertension were not significant different（P〉0.05）. Conclusion There are some risk reasons of chronic hepatitis with older,coninfectiong with other hepatitis virus,hepatic cirrhosis and non-anti-viral treatment.