利用乳酸菌降解草酸预防结石的研究进展

Research progress on urolithiasis prevantion via oxalate degradation

人体中尿草酸浓度过高是引起泌尿系统结石的一个重要因素。泌尿系统结石的形成受到遗传、环境、饮食、药物和疾病等多方面因素的影响。人体中尿草酸浓度过高,对肾上皮细胞具有毒性,并造成上皮的损伤,同时上皮细胞也主动摄入晶体、分泌大分子物质,二者相互作用最终导致结石的形成。降低尿草酸的浓度是预防泌尿系统疾病的重要因素。国内外研究发现乳酸菌具有降解草酸的能力,乳酸菌是益生菌,具有较好的生物安全性,可成为临床预防草酸钙结石的有效途径。

The high concentration of oxalic acid in human urine is an important factor for a urinary stone.The formation of the urinary stone is influenced by heredity,environment and food,medicine,sickness and many factors.If the concentration of oxalic acid in human urine is too high,it will hurt the Kidney epithelial cell.The interaction between oxalate and epithelial cells produces poisonous substance,which hurt epidermis.The epithelial cells also intake crystal and excrete macromolecule substance.The interaction of oxalic acid and epithelium leads to the formation of calculus.The key factor of preventing the disease is decreasing the concentration of oxalate.Lactic acid bacterium,which has a better biological safety,is one of probiotics.Researches home abroad find that lactic acid bacteria has the ability to degrade oxalate,which is one of effective ways to prevent calcinmoxalatecalculus in clinical practice.