影响PLGA微球突释的因素以及控制技术

Factors affecting the initial burst release of PLGA microspheres

PLGA微球注射剂是30年来药剂学研究热点之一,其研发和应用引起了医药领域的高度重视。针对目前PLGA微球存在突释高的问题,文中详细介绍了微球突释存在的原因以及突释阶段微球形态变化,重点介绍了影响突释的因素以及现阶段国内外控制突释的方法与技术,为研究PLGA微球突释提供思路。

PLGA microspheres have been studied widely for last 30 years.It had gained a lot of interests in medicine field.Focusing on the high initial burst release problem of PLGA microspheres,this article introduced the reason of burst and the forms of microspheres during the burst phase.We reviewed factors affecting the burst of PLGA micropsheres and the methods reducing the burst,which may have significant implications for the research on the burst.