摘要
目的利用Meta分析的方法,综合评价Resistin基因SNP-420C/G位点多态与中国汉族人2型糖尿病发病的相关性。方法计算机检索2001年1月～2010年7月CNKI、万方、VIP、中国生物医学服务系统(SinoMed)和PubMed数据库,并手工检索相关杂志,收集有关中国汉族人群Resistin基因-420C/G位点多态的基因型频率和/或等位基因频率的独立病例对照研究。在评价纳入研究质量,提取有效数据后,采用RevMan 4.2软件进行Meta分析。结果共纳入5个病例对照研究,包括2型糖尿病组709例,对照组572例。Meta分析结果显示:以CC基因型为暴露因素,具有CC基因型的人群2型糖尿病发病风险无明显增高[OR=1.02,95%CI(0.81,1.29)];以GG基因型为暴露因素,具有GG基因型的人群2型糖尿病发病风险无明显增高[OR=1.34,95%CI(0.95,1.90)]。结论本Meta分析结果提示,中国汉族人群Resistin基因SNP-420C/G位点多态可能与2型糖尿病的发病不相关。
Objective To investigate the association of the polymorphism of resistin gene SNP-420C/G and type 2 diabetes（T2DM） among the Chinese Han population.Methods Such databases as CNKI,WanFang database,VIP,SinoMed,and PubMed were electronically searched from January 2001 to July 2010 to collect case-control studies on polymorphism of resistin gene SNP-420C/G and T2DM among the Chinese Han population.The quality of the included studies was evaluated and the data was extracted.RevMan 4.2 software was used for meta-analyses.Results A total of five case-control studies were identified,involving 709 cases in the T2DM group and 572 cases in the control group.The results of meta-analysis showed that the Chinese Han population with CC genotypes of SNP-420 had no higher risks to T2DM（OR=1.02,95%CI 0.81 to 1.29）,and the Chinese Han population with GG genotypes of SNP-420 still had no higher risks to T2DM（OR=1.34,95%CI 0.95 to 1.90）.Conclusion Current evidence suggests that there is no association between the polymorphism of resistin gene SNP-420C/G and risk to T2DM among the Chinese Han population.
出处
《中国循证医学杂志》
CSCD
2011年第3期278-282,共5页
Chinese Journal of Evidence-based Medicine
