肛愈宁软膏促进肛周脓肿术后模型创面愈合的实验研究

Experimental study on Gang Yuning ointment promoting healing of analogue wound after operation for perianal abscess

目的探讨肛愈宁软膏对大鼠肛周脓肿术后模型创面愈合的影响。方法将64只Wistar大鼠随机分为肛愈宁组和马应龙组,每组32只。制备大鼠肛周脓肿术后创面模型,药物干预后,分别于造模后第3、7、10、14d取创面肉芽组织,观察病理变化。结果在创面愈合早期(3～7d),肛愈宁组毛细血管数量及成纤维细胞数量大于马应龙组(P<0.05)。结论肛愈宁软膏对肛周脓肿术后模型创面肉芽组织的生长有明显的促进作用,能显著促进创面的愈合。

Objective To explore the effect of Gang Yuning ointment on the analogue wound healing of the rats after operation for perianal abscess.Methods Sixty-four Wistar rats were randomly divided into two groups：Gang Yuning group and Ma Yinglong group.The pathological changes was observed after operation for perianal abscess and treated with ointments.The granulation tissue of wound was obtained on the 3th,7th,10th,14th day.Results In the wound healing nonage（3～7d）,there were more blood capillaries and mechanocytes on the wound of Gang Yuning group than that of Ma Yinglong group（P0.05）.Conclusion Gang Yuning ointment can accelerate growth of the granulation tissue on analogue wound after operation for perianal abscess.It can promote wound healing.