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非对称性二甲基精氨酸和冠状动脉性心脏病及其危险因素的关系 被引量：8

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摘要 目前有研究表明高血压、糖代谢异常等情况下,血浆非对称性二甲基精氨酸（asymmetric dimethyl-arginine,ADMA）浓度升高[1-2]。ADMA作为内源性一氧化氮合成酶（NOS）的抑制剂,通过抑制一氧化氮（NO）生成可加速动脉粥样硬化（AS）的进展,加重斑块的炎症反应,影响冠状动脉粥样硬化性心脏病（冠心病）患者的远期预后[3]。他汀类药物和冠状动脉支架置入术（PCI）作为冠心病治疗的主要药物和方法,
作者 卜云涛 边波 万征
机构地区 天津医科大学总医院心内科
出处 《中国循证心血管医学杂志》 2011年第1期63-66,共4页 Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词 非对称性二甲基精氨酸 冠状动脉性心脏病 冠状动脉粥样硬化性心脏病 危险因素 一氧化氮合成酶 冠状动脉支架置入术 他汀类药物 糖代谢异常
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献9

  • 1Lu CW, GuoZ, FenM, et al. Ex vivo gene transfen'ing of humandimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothe- lial eells[J]. Atherosclerosis,2010,209( 1 ) :66-73.
  • 2冯薇,曲秀芬,夏伟,宋影.冠心病患者二甲基精氨酸与颈动脉内膜厚度关系的临床研究[J].黑龙江医学,2008,32(12):888-890. 被引量：3
  • 3蒋海河,林国强,刘一,李迎秋.原发性高血压患者血清非对称性二甲基精氨酸的测定及临床意义的研究[J].中国全科医学,2008,11(6):468-469. 被引量：6
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  • 5赵雷,张吉凤,赵佳怡,祝金明,李淑梅.ADMA对人脐静脉内皮细胞粘附功能影响的体外研究[J].中国实验诊断学,2010,14(2):185-187. 被引量：7
  • 6Krzyzanowska K,Mittermayer F,Wolzt M,et al. Asymmetric dim- eth-ylarginine predicts cardiovascular events in patients with type 2 diabetes [ J ]. Diabetes Care,2007,30 ( 7 ) : 1834-1839.
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二级参考文献26

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共引文献13

同被引文献99

  • 1陶则伟,黄元伟.心室重塑及其转归[J].武警医学,2005,16(10):773-775. 被引量：8
  • 2胡玲爱,蔡久英.内皮功能紊乱与冠心病致病机制研究进展[J].医学综述,2006,12(4):207-209. 被引量：10
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33008
  • 4方媛,刘治全,牟建军,贺浪冲,王嗣岑.血压盐敏感者一氧化氮系统与非对称性二甲基精氨酸和补钾的作用[J].中华高血压杂志,2006,14(10):797-801. 被引量：19
  • 5Gennaro Colonna VD, Bianchi M, Pascale V, et al. Asymmetric dimethylarginine( ADMA ): An endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule. Med Sci Monit, 2009, 15: 91-101.
  • 6Schulze F, Lenzen H, Hanefeld C, et al. Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. Am Heart J, 2006, 152: 1-8.
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  • 9Sydow K, Munzel T. ADMA and oxidative stress. Atherosclerosis Suppl, 2003, 4 : 41-51.
  • 10Zweier JL;Talukder MAi The role Of oxidants and free radicals in reperfusion injury. Cardiovasc Res, 2006, 70 : 181-190.

引证文献8

二级引证文献18

中国循证心血管医学杂志
2011年 第1期

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