摘要
目的建立左旋多巴的微生物限度检查的方法。方法采用《中国药典》(2010年版)二部微生物限度检查法对左旋多巴进行微生物限度检查进行验证。结果左旋多巴具有抑制金黄色葡萄球菌活性作用,因此选择薄膜过滤法消除其抑菌活性。结论本品细菌数检查可用薄膜过滤法,霉菌及酵母菌检查可用平皿法,大肠埃希菌检查可用常规法。
Objective To establish the microbial limit test for levodopa.Methods Membrane filtration and Aerobic plate-count method was used.Results Levodopa could inhibit the activity of staphylococcus aureus.The membrane filtration method could eliminate the antibacterial effect of levodopa.Conclusion The aerobic plate-count can be used to test the count of molds and yeasts.Membrane filtration can be used to examine the bacterial.Escherichia coli of levodopa can be examined by routine test method.
出处
《今日药学》
CAS
2011年第1期37-39,共3页
Pharmacy Today
关键词
左旋多巴
抑菌性
微生物限度
levodopa
antibacterial activity
microbial limit
