西安地区食管癌的遗传流行病学

A genetic epidemiological study on esophageal cancer in Xi'an

目的： 分析西安地区食管癌的分离比、遗传度和病例亲属的标准化死亡比（ＳＭＲ）． 方法： 应用遗传流行病学和病例对照研究方法，调查分析了西安地区２１１例食管癌病例和１８３例对照的亲属中食管癌发病情况． 结果： 病例组Ⅰ， Ⅱ级亲属中食管癌的发病率（分别为２．９５％ ， ０．６４％ ）均高于对照组（０．３２％ ），分离比为０．００８２～０．０２９４，不符合单基因遗传规律，Ⅰ，Ⅱ级亲属加权平均遗传度为５０．０２％ ，其中８４例病例各级亲属ＳＭＲ均大于１． 结论： 食管癌的遗传背景是食管癌的发病因素之一，但不是主要因素．

AIM: To evaluate the segregation ratio, the hereditability (h2) and the standardized mortality ratio (SMR) of esophageal cancers in Xi'an (EC). METHODS: A genetic epidemiological case control study was carried out to study the genetic factors of EC in Xi'an. RESULTS: The in cidence of Ⅰ and Ⅱ degree relatives of the cases was 2.95% and 0.64% respectively, significantly higher than that of the relatives of the controls (0.32%). The segregation ratio was 0.0082~0.0294 and the genetic model belonged to polygenetics. The weighed average h2 of Ⅰ and Ⅱ degree relatives was 50.02% and SMR values of 84 EC cases were more than 1 in both Ⅰ and Ⅱ degree relatives. CONCLUSION: The genetic background, though not a main one, is a risk factor of EC in Xi'an.