甲状腺机能亢进症患者血清骨代谢指标的改变

Changes of Bone Metabolism Markers in Hyperthyroidism

目的 观察甲状腺机能亢进症 (甲亢 )患者骨代谢指标的改变。 方法 对 40例甲亢患者及40例健康对照者的血清骨代谢指标测定 ,包括 型溶胶原肽酶羧基末端 ( PICP)、骨钙素 ( OSC)、碱性磷酸酶 ( AL P)。 结果 甲亢组 PICP、OSC、AL P均明显高于对照组 ( P<0 .0 1) ,且分别与 FT3及 FT4呈正相关 ( P<0 .0 1)。 结论 甲亢时骨转换加速可能与甲状腺激素直接参与有关。

To assess changes of biochemical markers of bone metabolism in hyperthyroidism \ Methods\ Biochemical markers of bone metabolism such as carboxy terminal propeptide of type I procollagen(PICP), osteocalcin(OSC),alkaline phosphatase(ALP) and serum FT\-3,FT\-4 were measured in 40 patients with hyperthyroidism and 40 healthy subjects \ Results\ The levels of PICP、OSC and ALP in hyperthyroidism patients were all higher than healthy subjects(P<0 01),positive correlation was seen between bone metabolism markers and serum FT\-3,FT\-4 in patients with hyperthyroidism \ Conclusion\ Thyroid hormone might speed up bone metabolism directly \;