四氯二苯并二恶英与妇科疾病

Research Progress of Correlation Between TCDD and Gynecological Diseases

四氯二苯并二恶英(tetrachlorodibenzodioxin,TCDD)是毒性最大的化合物之一,可损伤多种脏器功能并具有免疫抑制和致癌作用。TCDD可导致多种妇科疾病,如子宫内膜异位症、卵巢癌和卵巢功能早衰等,并在一定程度上促进这些疾病的发展。然而,据流行病学调查发现,暴露在TCDD中却使另外一种妇科疾病——子宫肌瘤的发病率降低。因此,研究TCDD与妇科常见病的关系可进一步认识TCDD的特性及作用机制,并为预防这些疾病提供帮助。

2,3,7,8-tetrachlorodibenzo-p-dioxin（TCDD） is one of the most hazardous compounds,causing impairment of many organs,immunosuppression and carcinogenesis.TCDD could result in pathogenesis of some gynaecological diseases,such as endometriosis,ovarian tumor and premature ovarian failure,and promote deterioration of these diseases.However,according to the epidemiological study,TCDD could reduce the incidence of uterine myoma.So,study on TCDD and its relationship with gynaecological diseases will add our knowledge of TCDD characteristics and its mechanism,which could help us to prevent some gynaecological diseases.