中西结合治疗产ESBLs大肠杆菌引起的种鸭输卵管炎

Treating Seed Duck Salpingitis Caused by Producing-ESBLs Escherichia coli with Antibacterial and Chinese Traditional Medicine

采用实验室方法分离鉴定了种鸭输卵管炎细菌,并对分离菌进行超广谱β-内酰胺酶(ES-BLs)检测和其对24种抗菌药的敏感性测定。结果显示,分离细菌为产ESBLs大肠杆菌。药敏试验结果表明,该菌对兽医临床中常用的β-内酰胺类抗生素、氟喹诺酮类、氯霉素类、氨基糖苷类等均产生耐药性;对黏杆菌素、亚胺培南、美罗培南敏感;β-内酰胺类药物与酶抑制剂联用能使药物对细菌的最低抑菌浓度(MIC)降低。采用复方β-内酰胺类药物结合中药治疗一周,取得了良好的治疗效果,种鸭产蛋率恢复至86%。

Bacteria which caused seed duck salpingitis were isolated and identified by laboratory means and its sensitivities to the extended spectrum β-lactamase（ESBLs）,24 species antibacterial and 5 pharmacopoeia compound pharmaceutical were determined.The results showed that the separated bacterium was Escherichia coli producing ESBLs.Tests of drug sensitivities showed that the bacterium produced drug resistance to many usual veterinary clinical drugs,such as β-lactam antibiotics,quinolones,chloramphenicoles,aminoglycoside,and so on.The bacteria was sensitive to polymycin,imipenem,meropenem,β-lactam drugs combined with enzyme inhibitor could decrease the minimum inhibitory concentration（MIC）.Therefore the best effective treating measures for salpingitis was using β-lactam drug and enzyme inhibitor combined with Chinese traditional medicine.One week after treatment,the laying rate of seed duck was recovered to 86%.