摘要
以甲磺酸帕珠沙星(1)为药物,以壳聚糖修饰的多壁碳纳米管(MWCNT-CS)/壳聚糖半互穿网络水凝胶(C)为载体,采用浸泡法合成了不同MWCNT-CS含量(0%,2.5%,10.0%)的三种载药水凝胶[C0(1),C2.5(1)和C10.0(1)]。研究了C(1)中MWCNT-CS含量以及pH对1释放性能的影响。结果表明,C10.0(1)具有较好的缓释性能。
Depending upon chitosan(CS) modified multiple-walled carbon nanotubes(MWCNT-CS) amount(0%,2.5%,10.0%),three drug-loaded hydrogel[C0(1),C2.5(1),C10.0(1)] were prepared by soaking method using Pazufloxacin mesilate(1) as the drug and MWCNT-CS/semi-IPN hydrogels as the drug carriers.Effect of content of CS-MWCNT in C(1) and pH on controlled release performance of 1 were investigated.The results showed that the C10.0(1) possess good controlled release performance.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第2期166-169,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(50772133)
湖南省科学技术厅科技计划资助项目(2010GK3113)
中央高校基本科研业务专项资金资助项目(201012200146)
中南大学理科发展基金资助项目(10SDF04)
关键词
甲磺酸帕珠沙星
多壁碳纳米管
半互穿网络水凝胶
制备
缓释性能
multi-walled carbon nanotubes
semi-interpenetrating hydrogell
preparation
controlled release performance