摘要
以2-溴噻吩为原料,经溴代反应和格氏试剂反应制得2,2'∶5',5'-三联噻吩(1);1乙酰化后与4-取代苯甲醛发生亲核加成反应得到α,β-不饱和酮(3a~3e);3与80%水合肼发生关环反应,合成了5个α-三联噻吩-吡唑啉类化合物(4a~4e),收率74.3%~89.7%。其结构经1H NMR,IR和元素分析表征。3和4均为新化合物。
2,2′ ∶ 5′,5′-Terthiophene(1) was prepared by the bromination and Grignard reaction of 2-bromothiophen.α,β-unsaturated ketones(3a^3e) were obtained by acetylation of 1 and then nucleophilic substitution with 4-substituted benzaidehyde.Five terthiophene-pyrazoline derivatives(4a^4e) were synthesized by cyclization of 3 with 80% hydrazine hydrate in yield of 74.3%~89.7%.The structures were confirmed by 1H NMR,IR and elemental analysis.3 and 4 were new compounds.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第2期199-203,共5页
Chinese Journal of Synthetic Chemistry
基金
广东省自然科学基金资助项目(7006672)
广东省科技计划资助项目(2007A020300009-8)