三联噻吩-吡唑啉类化合物的合成

Synthesis of Terthiophene-Pyrazoline Derivatives

以2-溴噻吩为原料,经溴代反应和格氏试剂反应制得2,2'∶5',5'-三联噻吩(1);1乙酰化后与4-取代苯甲醛发生亲核加成反应得到α,β-不饱和酮(3a～3e);3与80%水合肼发生关环反应,合成了5个α-三联噻吩-吡唑啉类化合物(4a～4e),收率74.3%～89.7%。其结构经1H NMR,IR和元素分析表征。3和4均为新化合物。

2,2′ ∶ 5′,5′-Terthiophene（1） was prepared by the bromination and Grignard reaction of 2-bromothiophen.α,β-unsaturated ketones（3a^3e） were obtained by acetylation of 1 and then nucleophilic substitution with 4-substituted benzaidehyde.Five terthiophene-pyrazoline derivatives（4a^4e） were synthesized by cyclization of 3 with 80% hydrazine hydrate in yield of 74.3%~89.7%.The structures were confirmed by 1H NMR,IR and elemental analysis.3 and 4 were new compounds.