期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

2-氨基-4-(4-甲氧基苯基)-6-(哌啶-1-基)-3,5-二腈基吡啶的三组分合成与表征

Three-component synthesis and characterization of 2-amino-4-(4methoxyphenyl)-6-(piperidin-1-yl)-3,5-dicarbonitrile pyridine
下载PDF
导出
摘要 在甲醇溶剂中,以丙二腈、4-甲氧基苯甲醛、哌啶为原料,常温下经三组分一锅法合成得到了未见文献报道的新化合物2-氨基-4-(4-甲氧苯基)-6-(哌啶-1-基)-3,5-二腈基吡啶,收率40%。其化学结构经过1 H NMR、MS及单晶衍射进行表征。 Novel 2-amino-4-（4-methoxyphenyl）-6-（piperidin-1-yl）pyridine-3,5-dicarbonitrile is synthesized using malononitrile,4-methoxybenzaldehyde and piperidine as starting material in methanol by one-spot.The yield is 40% with three-component reaction at room temperature.The structure is confirmed by 1H NMR,MS and X-ray single crystal diffraction.
作者 李元祥 吴峰
机构地区 怀化学院化学与化学工程系
出处 《重庆大学学报（自然科学版）》 EI CAS CSCD 北大核心 2011年第3期121-125,共5页 Journal of Chongqing University
基金 湖南师范大学化学生物学及中药分析教育部重点实验室开放基金课题资助项目(KLCBTCMR2008-05) 湖南省自然科学基金资助项目(09JJ6023) 湖南省教育厅科学研究项目(09C759) 怀化市科技计划项目(20093109)
关键词 三组分一锅法 吡啶 合成 晶体结构 表征 three component one-pot pyridine synthesis crystal structure characterization
分类号 TQ031.2 [化学工程]
  • 相关文献

参考文献15

  • 1YOSHIHARU O, MITSUO M. Biotransformation of nobiletin by aspergillus niger and the antimutagenic activity of a Metabolite 4' Hydroxy-5, 6, 7, 8, 3' pentamethoxyflavone[J]. Journal of Natural Products, 2004, 67(11): 1876-1878.
  • 2PETER I. K, DEBRA A V, GORDON P G, et al. Alkaloids with human 3-opioid receptor binding affinity from the Australian rainforest tree peripentadenia mearsii[J]. Journal of Natural Products, 2007, 70(12): 1946-1950.
  • 3MARIA J G, JOSE M Z, JAVIER N, et al. Synthesis and evaluation of new ethyl 2,3 dihydrc-3-oxoisothiazolo [ 5, 4 b ] pyridine-2 alkanoate derivatives as potential herbicides[J]. Pesticide Science, 1997, 49(2): 148-156.
  • 4BARNABY C H M, JULIE A Z, JUANITA W, et al. Structure-activity relationship study of prion inhibition hy 2-aminopyridine-3, 5 dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics[J]. Journal of Medicinal Chemistry, 2007, 50(1): 65 73.
  • 5VAGANOVA E, WACHTEI. E, LEITUS G, et al. Photoinduced proton transfer in a pyridine based polymer gel[J]. The Journal of Physical Chemistry B, 2010, 114(33): 10728-10733.
  • 6BARLOW B C, BURGESS I J. Electrochemical evaluation of 4-(dimethylamino)pyridine adsorption on polycrystalline gold[J]. Langmuir, 2007, 23(3): 1555-1563.
  • 7HUANG J S, XIE J, KUI S C F, et al. Self-assembly of a cyclic metalladecapyridine from the reaction of 2,6 bis ( bis ( 2-pyridyl ) methoxymethane ) pyridine with silver(I)[J]. Inorganic Chemistry, 2008, 47(13): 5727-5735.
  • 8URANKAR D, PINTER B, PEVEC A, et al. Clicktriazole N2 coordination to transition-metal ions is assisted by a pendant pyridine substituent [J]. Inorganic Chemistry, 2010, 49(11): 4820-4829.
  • 9MURRAY T J, ZIMMERMAN S C, KOL()TUCHIN S V. Synthesis of heterocyclic compounds containing three contiguous hydrogen bonding sites in all possible arrangements [ J ]. Tetrahedron, 1995, 51 ( 2 ):635 648.
  • 10GHOZLAN S A S, HASSANIEN A Z A. 13-Amino-13( pyrid4-yl ) acrylonitrile in heterocyelic synthesis: synthesis of some new pyridine, pyridone, pyrazole, thiophene, fused pyrimidine and triazine derivatives[J]. Tetrahedron, 2002, 58(46); 9423-9429.
重庆大学学报（自然科学版）
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部