2007年至2009年我院中药注射剂不良反应报告分析

Statistical Analysis on Adverse Drug Reaction Reports of Traditional Chinese Medicine Injections from 2007 to 2009

目的了解医院使用中药注射剂的药品不良反应情况,为临床安全用药提供参考。方法采用回顾性调查分析方法,对医院2007年至2009年收集的121例中药注射剂所致不良反应报告进行统计分析。结果 121例药品不良反应涉及17种中药注射剂;0～9岁年龄组患者35例,比例最高(30.58%);临床表现以皮肤及其附件损害多见,其次为全身性损害及用药部位损害,较严重的有呼吸困难、过敏性休克等。结论应加强中药注射剂不良反应的监控工作,避免和预防不良反应的发生。

Objective To understand the status of adverse drug reactions（ADR） due to traditional Chinese medicine（TCM） injections in our hospital and to provide reference for clinical safe medication.Methods 121 cases of serious ADR reports of TCM injections collected in our hospital from 2007 to 2009 were statistically analyzed using retrospective study method.Results 121 cases of ADR were involved with 17 types of TCM injections.The patients（35 cases） in the age group of 0-9 years old had the highest proportion（30.58%）.The clinical manifestations of ADR were mainly lesions of skin and accessories,followed by general damage and partial damage at the local part of drugs use.The severe clinical manifestations included anaphylactic shock and dyspnea.Conclusion ADR monitoring for TCM injections should be reinforced to reduce and prevent its occurrence.