塞克硝唑与甲硝唑治疗慢性鼻窦炎厌氧菌的疗效比较

Comparision of Efficiency of Secnidazole and Metronidazole in the Treatment of Anaerobic-Induced Chronic Sinusitis

目的分析比较塞克硝唑片与甲硝唑片治疗慢性鼻窦炎厌氧菌的效果,为寻找新的治疗药物提供参考依据。方法对耳鼻咽喉头颈外科2007年10月-2009年7月间因慢性鼻窦炎厌氧菌就诊的患者中随机选出采用塞克硝唑片或甲硝唑片的患者共451例,分为塞克硝唑片治疗组232例(试验组)与甲硝唑片治疗组219例(对照组),其他治疗药物与手段相同,持续用药5 d后,比较试验组与对照组患者窦腔脓性分泌物中厌氧菌的种类数量。结果治疗5 d后,两组患者窦腔脓性分泌物中厌氧菌的种类显著减少,其中试验组中厌氧菌种类由用药前的40种降为6种,而对照组由39种减至11种,其有效率分别为85.0%7、1.8%,差异均有统计学意义(P<0.05)。结论塞克硝唑片与甲硝唑片治疗慢性鼻窦炎厌氧菌均可获得较好的疗效,且安全性较好,但是前者的效果要优于后者,值得参考。

Objective To compare effects of the secnidazole and metronidazole tablets in treatment of anaerobic-induced chronic sinusitis,and to find new medicine for this disease. Methods 451 chronic sinusitis patients were chosen from October 2007 to July 2009 in our hospital, and were divided into secnidazole treatment group （test group） and metronidazole treatment group（ control group）. After 5 days＇ continual treatment, the type and quantity of anaerobic bacteria in the purulent secretion from two groups of patients were analyzed. Results After 5 days,the anaerobic bacteria in purulent secretions of two groups were signifi- candy reduced in the types, the types of anaerobic bacteria in the test group were dropped from 40 to 6, while the control group from 39 to 11, the effective rates were 85.0% ,71.8 %, respectively. The difference was statistically significant （P 〈 0.05 ）. Conclusion Both secnidazole tablets and metronidazole tablets were effective and safe in the treatment of chronic sinusitis; secnidazole tablets were better than metronidazole tablets.