甲状腺功能亢进患者药物治疗后脂联素水平变化

Changes of Serum Adiponectin in Patients with Hyperthyroidism before and after Antithyroid Drug Therapy

目的探讨甲状腺功能亢进患者经抗甲状腺药物治疗前后脂联素的变化及相关因素。方法 97例甲状腺功能亢进患者经6个月抗甲状腺药物治疗后,观察甲状腺功能恢复正常的78例患者治疗前后空腹血糖、胰岛素、血脂、脂联素水平和体重指数;对治疗前后血清脂联素与BMI、甲状腺激素、血脂、胰岛素抵抗指数等变量进行相关分析。结果治疗6个月后FT3、FT4、TSH恢复正常,BMI升高,HOMA-IR下降,血清脂联素水平下降。治疗前,血清脂联素与BMI、HOMA-IR呈负相关,与FT4、FT3呈正相关;治疗后,血清脂联素仍然与FT4、FT3呈正相关,与BMI呈负相关。控制BMI、性别、年龄等因素后的偏相关分析表明血清脂联素仍然与FT4呈正相关。结论甲亢患者血清脂联素升高,甲状腺功能正常后恢复正常,甲状腺激素水平影响脂联素水平。

Objective To investigate the changes of serum adiponectin and correlation factors in patients with hyperthyroidism before and after antithyroid drug therapy. Methods Ninety-seven patients with hyperthyroidism were treated with antithyroid drug, and seventy-eight patients achieving euthyroid status after 6 months of antithyroid drug therapy were recruited. FBG, insulin,FT3, FT4, TSH, TG, TC, BMI and serum adiponectin level were measured before and after 6 months treatment i correlation analysis between adiponectin and all metabolic parameters of the patients was performed before and after treatment. Results Euthyroid status was achieved, BMI was increased, HOMA-IR and adiponeetin level were decreased after 6 months treatment. Changes in BMI, HOMA-IR, FT3, Fr4 were correlated with changes in serum adiponectin before treatment ; After treatment, serum adiponectin level was also correlated with BMI, FT3, FT4. After controlling the BMI changes, sex and age, partial correlation also showed the correlation between serum FT3, FT4 and adiponectin. Conclusion The serum adiponectin level was increased in hyperthyroidism and decreased after antithyroid therapy;thyroid hormone can influence changes of serum adiponectin.